relenza contraindications

The clinical impact of substitutions associated with reduced susceptibility to zanamivir and other neuraminidase inhibitors is variable and may be strain-dependent. 2005 - 2021 WebMD LLC. Due to limited and inconclusive data, the efficacy of Relenza in the prevention of influenza in the nursing home setting has not been established. Contraindications. Zanamivir is eliminated through renal filtration. RELENZA is contraindicated in patients with history of allergic reaction to any ingredient of RELENZA, including milk proteins [see Warnings and Precautions (5.2), Description (11)]. Relenza should not be taken by individuals who experience hypersensitivity reactions to lactose (e.g. RELENZA is contraindicated in patients with severe milk protein allergy. Use of . It prevents . The use of Relenza is contraindicated in patients with known hypersensitivity to any ingredient of the preparation (see Section 6.1 List of Excipients). 5 WARNINGS AND PRECAUTIONS 5.1 Bronchospasm RELENZA is not recommended for treatment or prophylaxis of influenza in individuals with underlying airways disease (such as asthma or chronic . Relenza should be used for the treatment and prevention of influenza only when reliable epidemiological data indicate that influenza is circulating in the community. Found insidephosphate/zanamivir Zanamivir: Treatment of uncomplicated influenza virus infection (A & B) in pts 7y/o who are symptomatic for 2d. Prophylaxis of c infectious CONTRAINDICATIONS: tion c high-risk pts, Hypersensitivity. A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Relenza therapy, taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman. Total clearance ranges from 2.5 to 10.9 L/h as approximated by urinary clearance. Contraindications. Five patients were excluded due to undetectable serum concentrations at all time points or 1.5 hours post-dose, suggesting inadequate drug delivery. Found inside Page A-18Relenza Cont . Table 1 : Summary of Adverse Events 21.5 % Incidence During Treatment 3 % RELENZA MICROBIOLOGY Mechanism of CONTRAINDICATIONS Drug Interactions : No clinically significant pharmacokinetic analysis in patient studies Skip to Main Content; U.S. National Library of Medicine. Found inside Page 192May decrease hemoglobin and neutrophil , WBC , and platelet counts . zanamivir Relenza CONTRAINDICATIONS Contraindicated in patients hypersensitive Pregnancy risk category B to drug or its components . Systemic exposure to zanamivir is low following administration by inhalation; however, there is no information on secretion of zanamivir into human breast milk. Virion release from infected cells and spread with the respiratory tract are inhibited due to blockade of . Further management should be as clinically indicated or as recommended by the national poisons centre. In this study, the incidence of symptomatic influenza was reduced from 1.4% (23 of 1,685) with placebo to 0.2% (4 of 1,678) with Relenza (83% protective efficacy; 95% CI: 56% to 93%, p<0.001). In the 2009 H1N1 swine flu pandemic, Tamiflu was shown by the World . There is a limited amount of data (less than 300 pregnancy outcomes) from the use of zanamivir in pregnant women. 2 Relenza is contraindicated in patients with history of allergy to milk protein. Lactose monohydrate (which contains milk protein). Animal studies indicate no clinically meaningful effects of zanamivir on male or female fertility (see section 5.3). Relenza inhalation powder is packed in a circular aluminium foil disk (a Rotadisk) with four regularly distributed blisters. In the severe renal impairment group from the single IV zanamivir dose trial subjects were sampled after a dose of 2 mg or twice to four times the expected exposure from inhalation. You will be advised on the appropriate dose and the length of treatment. marketing authorisation with respect to patient population, contraindications and posology amongst others. The term influenza refers to illness caused by influenza virus. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). Older patients: At the therapeutic daily dose of 20mg, bioavailability is low (4-17%), and as a result there is no significant systemic exposure of patients to zanamivir. 5 WARNINGS AND PRECAUTIONS. Relenza Pharmacologic class: Neuraminidase inhibitor Therapeutic class: Antiviral Pregnancy risk category C Action Inhibits influenza virus neuraminidase, an enzyme essential for viral replication Availability Powder for inhalation: 5 mg/blister Indications and dosages Prevention of influenza Adults and children ages 5 and older: . Product specifics Oseltamivir (Tamiflu) Zanamivir (Relenza) Contraindications None. Glaxo Wellcome UK Ltd trading as GlaxoSmithKline UK, Date of first authorisation: 24 June 1999, 980 Great West Road, Brentford, Middlesex, TW8 9GS, UK. Found inside Page 727Carcinogenesis has been found in rodents with chronic oral administration . zanamivir ( Relenza ) , oseltamivir ( Tamiflu ) Contraindications Hypersensitivity Warnings . See Patient Variables . Precautions Zanamivir : allergic JQA=E2pCYeAA!aF@U0a8!@(Uia3{*`eT~)3,63~ cP The use of RELENZA is contraindicated in patients with known hypersensitivity to any ingredient of the preparation (see section 6.1 List of excipients). Contraindications: Zanamivir: hypersensitivity to any component of the product including lactose (milk proteins) Warnings: Zanamivir: airway disease (e.g., COPD, asthma) Oseltamivir: hereditary fructose intolerance (with suspension), renal impairment, self-injury and delirium, and serious skin reactions Table Footnotes # This designates a brand-name drug with FDA "A"-rated generic . The volume of distribution of zanamivir in adults is approximately 16 L, which approximates to the volume of extracellular water. Although Tamiflu and Relenza were able relieve flu-like symptoms in adults by only half a day, there was no foreseeable difference in children. Clinically significant drug interactions are unlikely. Found inside Page 1079Zanamivir ( za NA mi veer ) U.S. Brand Names Relenza Canadian Brand Names Relenza Generic Available No Use Treatment of Contraindications Hypersensitivity to zanamivir or any component of the formulation Warnings / Precautions

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