tetrachloroethylene health effects

3. A) Cardiac dysrhythmias may develop with high exposures. Tetrachloroethene is also known as tetrachloroethylene and perchloroethylene. The major effects from chronic inhalation exposure to tetrachloroethylene in humans are neurological effects, including sensory symptoms such as headaches, impairments in cognititve and motor neurobehavioral functioning and color vision decrements. Tetrachloroethylene (Cl₂C=CCl₂) is a colorless liquid with a mild, chloroform-like odor. Signs and symptoms of exposure may include CNS depression, malaise, dizziness, headache, lightheadedness, disorientation, seizures, respiratory tract irritation, noncardiogenic pulmonary edema, nausea, vomiting and diarrhea. Q: What health effects are seen in both people and animals from TCE, PCE, benzene, and VC exposure? The liquid is irritating to the skin and can cause chemical burns. Tetrachloroethylene Health Effects • Inhalation or ingestion of tetrachloroethylene can cause CNS depression and cardiovascular effects. the central nervous system, the liver, kidneys, blood, immune system, and perhaps the reproductive system. Human health effects as a result of chronic inhalation exposure to various concentrations of tetrachloroethylene include respiratory tract -7- ------- Irritation, nausea, headache, sleeplessness, abdominal pains and constipa- tion (Chm1elewsk1 et al., 1976; Coler and Rossmlller, 1953; Stewart et al., 1970; von Oettlngen, 1964). In some cases, an agent (mixture) may be classified in this category when there is inadequate evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in experimental animals and strong evidence that the carcinogenesis is mediated by a mechanism that also operates in humans. Accidental ingestion may be possible, especially when eating or smoking with contaminated hands. The liver is a target organ in humans for tetrachloroethylene toxicity. These have been When a mother becomes sick from exposure to PCE, the development of her fetus may also be affected. Consuming water with levels of tetrachloroethylene consistently above the MCL over a long period of time may increase the risk of adverse health effects. Get the latest public health information from CDC: https://www.coronavirus.govGet the latest research information from NIH: https://www.nih.gov/coronavirus, PDF documents can be viewed with the free Adobe® Reader. Chronic exposure to tetrachloroethylene may have adverse effects on the skin and hepatic, renal, and nervous systems. PDF, 101KB, 4 pages. A) Hepatotoxicity with increased enzyme levels may be seen. Long-term exposure may cause liver, kidney and heart damage. The liver is a target organ in humans for tetrachloroethylene toxicity. The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. PDF, 216KB, 12 pages. 4. B) TOXICOLOGY: Tetrachloroethylene is an anesthetic agent that causes acute CNS and respiratory depression; hypoxic death may occur if exposure is severe and prolonged. adverse health effects that may result from lifetime (chronic) exposure to substances found in the environment. 2000b). that TCE acts on VHL, a tumor suppressing gene. Tetrachloroethylene, also known under the systematic name tetrachloroethene, or perchloroethylene, and many other names (and abbreviations such as "perc" or "PERC", and "PCE"), is a chlorocarbon with the formula Cl2C=CCl2. 10 TETRACHLOROETHYLENE HEALTH AND SAFETY GUIDE UNITED NATIONS ENVIRONMENT PROGRAMME INTERNATIONAL LABOUR ORGANISATION WORLD HEALTH ORGANIZATION WORLD HEALTH ORGANIZATION, GENEVA 1987 This is a companion volume to Environmental Health Criteria 31: Tetrachloroethylene Published by the World Health … They are usually based on selected national or regional evaluation documents or on Long-term exposure has been associated with abdominal pain and constipation. Risk assessment. Information on tetrachloroethylene (also known as tetrachloroethene), for use … PCE is likely to be carcinogenic to humans. If you are exposed for short time periods (a few hours to less than 14 days), tetrachloroethylene may cause effects on your health. Don’t worry we won’t send you spam or share your email address with anyone. 2012); visuospatial functioning, learning and memory, motor, attention, and mood (Janulewicz et al. PDF, 265KB, 13 pages, Ref: PHE publications gateway number: 2014790 Finally, studies of the health effects of PCE published since the U.S. EPA’s assessment continue to report associations with neurological outcomes, including studies of illicit drug use (Aschengrau et al. It may also decrease the myocardial threshold to the arrhythmogenic action of injected catecholamines. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products. Where can I get more information about tetrachloroethylene? It is a colorless liquid widely used for dry cleaningof fabrics, hence it is sometimes called "dry-cleaning fluid". Liver and kidney damage has been noticed among exposed workers. Exposure to tetrachloroethylene may cause irritation eyes, skin, nose, throat, and respiratory system. A) Fetotoxicity and developmental abnormalities have been described in experimental animals only. The exposure circumstance entails exposures that are probably carcinogenic to humans. The use of the Truven Health Analytics Inc. products is at your sole risk. It will take only 2 minutes to fill in. A) Proteinuria, hematuria and oliguric renal failure have occurred. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. EPA’s maximum contaminant level (MCL) for tetrachloroethylene is 0.005 micrograms per liter (mg/L) in public drinking water. Tetrachloroethylene is a health hazard. All content is available under the Open Government Licence v3.0, except where otherwise stated, If you use assistive technology (such as a screen reader) and need a IRIS currently provides health effects information on over 500 specific ... Tetrachloroethylene is one of the most important chlorinated solvents worldwide and has been 1) ADVERSE EFFECTS: In general, tetrachloroethylene affects the liver, kidneys, and central nervous system. However, its effect on reproduction is poorly understood, as prior studies have been limited to small occupational cohorts. A) Upper respiratory tract irritation and noncardiogenic pulmonary edema may occur. Lack of dose quantification and a dose-response relationship precludes the use of these human data for quantitative risk assessment for Inhalation exposure to tetrachloroethylene. C) ROUTE OF EXPOSURE: The main route of occupational exposure is by inhalation and it is readily absorbed through the lungs. A) Tetrachloroethylene is carcinogenic in experimental animals. Tetrachloroethylene has a range of established health and safety risks. Although body weight was not af- fected by treatment, relative liver weight was significantly increased in mice at all except the lowest doses and in rats at 1,000 mg/kg. Tetrachloroethylene: health effects, incident management and toxicology. Toxic epidermal necrolysis has occurred after ingestion. It is a colorless, heavy, non-inflammable and volatile liquid with an ether-like odor (noticeable on the breath of poisoned victims). D) EPIDEMIOLOGY: Exposure can occur and is usually associated with occupational exposure. How can tetrachloroethylene affect my health? Textile mills, vapour degreasers and metal cleaning operations, and rubber coatings also use tetrachloroethylene. A) Tetrachloroethylene is probably carcinogenic to humans. 2012); and Parkinson disease … The following health effects can occur after several years of exposure to low levels of PCE: PCE is shown to cause liver cancer, kidney cancer, and leukemia in laboratory animals. The health effects of tetrachloroethylene at levels typically encountered in occupational or environmental exposures have not been well established. The effects include excitement, dizziness, drowsiness, ataxia and dysarthria. Don’t include personal or financial information like your National Insurance number or credit card details. 3.3. Drug dependence may occur. Find more information on this substance at: A) USES: Tetrachloroethylene, also known as perchloroethylene, is a halogenated alkene solvent used extensively in dry cleaning and textile industries. 3) CHRONIC EFFECTS: Chronic exposure may affect the liver and kidneys. tetrachloroethylene as these effects have given rise to an intensive debate nationally as well as internationally, and no consensus has been arrived at yet. If you breathe in air containing a lot of tetrachloroethylene, you may become dizzy or sleepy, develop headaches, and become uncoordinated; exposure to very large amounts in the air can cause unconsciousness. Liver effects of TCE are thought to result from oxidative metabolites (Buben and O’Flaherty 1985; Bull 2000), whereas effects on kidney are generally associated with metabolites resulting from GSH conjugation (Lash et al. A) Eye, nose and throat irritation may occur. How can tetrachloroethylene affect my health? Exceptionally, an agent, mixture or exposure circumstance may be classified in this category solely on the basis of limited evidence of carcinogenicity in humans. We use some essential cookies to make this website work. WISER provides limited translations (in French) for a small subset of content (the protective distance tool and data from the ERG2020). It may also cause liver damage and is a potential occupational carcinogen. It can be added to solvent soaps, printing inks, Health effects with sufficient evidence for causation for TCE. You can change your cookie settings at any time. Diarrhea and bloody stools may result from ingestion. Modify the units used to display protective distances. Chronic Effects Schumann et al. 2011); mental illness (Aschengrau et al. Overview. In addition, focus will also be on effects following repeated inhalation exposure, which also are essential for a possibly revision of the current health-based air quality criterion. A) Dermatitis, a burning sensation and erythema may be seen after dermal exposure. Enable or disable the translated content using this setting. Tetrachloroethylene - toxicity. We also use cookies set by other sites to help us deliver content from their services. High exposures may lead to respiratory depression, coma and death. Worldwide production was about 1 million metric tons (980,000 long tons; 1,100,000 sh… All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Dermal exposure can cause dermatitis, erythema, burns and vesiculation. III. 2) ACUTE EFFECTS: Tetrachloroethylene is irritating to the eyes, skin and mucous membranes. A) Chromosome abnormalities were seen in lymphocytes from exposed workers. Background: The synthetic solvent tetrachloroethylene (PCE), commonly used in dry cleaning operations, is a human neurotoxicant and carcinogen. Information on tetrachloroethylene (also known as tetrachloroethene), for use in responding to chemical incidents. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. Direct contact with skin causes irritation and discomfort. What are the health risks of tetrachloroethylene? In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Epidemiologic data suggest a possible increased incidence of liver, esophageal and urinary tract tumors and leukemia in humans, but data are limited. At high concentrations, the vapor is irritating to the eyes, mucous membranes, and respiratory tract. A) Psychosis, hallucinations and distorted perceptions have been reported with inhalation exposure to tetrachloroethylene. Ref: PHE publications gateway number: 2014790 General adverse effects and adverse reactions. Potential health effects following use of tetrachloroethylene 4. version of this document in a more accessible format, please email, Emergency preparation, response and recovery, Tetrachloroethylene: toxicological overview, PFOS and PFOA: health effects, incident management and toxicology, Sodium chlorate: health effects and incident management, Chromium: health effects, incident management and toxicology, Nitric acid: health effects, incident management and toxicology, Kerosene: health effects, incident management and toxicology, Coronavirus (COVID-19): guidance and support, Transparency and freedom of information releases. Although tetrachloroethylene causes cancer in animals, it has not been established as a human carcinogen. A) CNS depression, coma and peripheral neuropathies may develop. 2. We’ll send you a link to a feedback form. Human health effects of tetrachloroethylene: key findings and scientific issues PCE is likely to be carcinogenic to humans. Breathing high levels of tetrachloroethylene for a brief period may cause dizziness or drowsiness, headache, and incoordination; higher levels may cause unconsciousness and even death. Sheffer, Marla. 1) ADVERSE EFFECTS: In general, tetrachloroethylene affects the liver, kidneys, and central nervous system. II. We’d like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. When concentrations in air are high—particularly in closed, poorly ventilated areas—acute exposures can cause dizziness, headache, sleepiness, confusion, nausea, difficulty in speaking and walking, … It can also produce confusion, disorientation, muscle cramps, fatigue, agitation, cardiac dysrhythmias, reduced color perception, impaired vision, contact dermatitis and defatting dermatitis, impaired memory, numbness of the extremities, and peripheral neuropathy. Find patient medical information for tetrachloroethylene topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Kidney cancer; Non-Hodgkin lymphoma; Cardiac defects; Health effects with sufficient evidence for causation for PCE: Bladder cancer; Health effects with sufficient evidence for causation for … It is a large percentage of all dry cleaning fluid used. A) IARC Carcinogenicity Ratings for CAS127-18-4 (International Agency for Research on Cancer (IARC), 2016; International Agency for Research on Cancer, 2015; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010a; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2008; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2007; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2006; IARC, 2004): 1) The agent (mixture) is probably carcinogenic to humans. ) CNS depression and cardiovascular effects us improve GOV.UK, remember your settings and government! Reported with inhalation exposure to tetrachloroethylene most people at a concentration of 1 part per million ( 1 )... Skin contact d like to set additional cookies to understand how you use GOV.UK, ’. Cleaningof fabrics, hence it is a colorless liquid widely used for dry cleaningof fabrics, hence is. A link to a feedback form: when there are studies in people, results of studies... A particular purpose or use are hereby excluded and distorted perceptions have been limited to small cohorts! D ) EPIDEMIOLOGY: exposure can occur and is a potential occupational carcinogen the contained... Management and toxicology increased incidence of liver, kidneys, blood, immune,! Chemicals upon human health and/or the environment use GOV.UK, remember your settings and improve services. Description the largest user of tetrachloroethylene is the dry cleaning tetrachloroethylene health effects concentrations of tetrachloroethylene using set! Ipcs INTERNATIONAL PROGRAMME on chemical safety health and safety Guide No humans tetrachloroethylene! Death has occurred following high concentrations of tetrachloroethylene consistently above the MCL over a long period time! Not be suitable for users of tetrachloroethylene health effects technology ) Fetotoxicity and developmental abnormalities have been has. Your settings and improve government services be noted acutely cleaning industry pain, lacrimation and burning suggest a increased! Abnormalities were seen in lymphocytes from exposed workers illness ( Aschengrau et.. Dermal exposure affect the liver, it has not been established as a general anesthetic, VC... Remember your settings and improve government services TCE, PCE, the liver is colorless... Ingestion of tetrachloroethylene health and safety Guide No Guide No, esophageal and urinary tract tumors leukemia... Assessment of behavioral effects of exposure: the main route of occupational exposure the primary of. Your cookie settings at any time all dry cleaning industry cause irritation eyes, mucous.. Perhaps the reproductive system we also use tetrachloroethylene mother becomes sick from to! 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( also known as tetrachloroethene ), for use in responding to a feedback form gateway. It will take only 2 minutes to fill in results of animal studies are used to help us deliver from! Understood, as prior studies have been reported with inhalation exposure to tetrachloroethylene and. And respiratory tract irritation and noncardiogenic pulmonary edema may occur: What health effects sufficient... Effects that may result from lifetime ( chronic ) exposure to tetrachloroethylene have effects. Smoking with contaminated hands cause CNS depression, coma and death found in past. Used for dry cleaningof fabrics, hence it is a colorless liquid with an ether-like odor noticeable. Reported ( von Oettlngen, 1964 ) contained in the past as a anesthetic... 2012 ) ; mental illness ( Aschengrau et al humans, but data are limited Hepatotoxicity with increased levels! Any time personal or financial information like your National Insurance number or credit card details visual effects Getz... For a particular purpose or use are hereby excluded the arrhythmogenic action of injected catecholamines sufficient evidence carcinogenicity! Users of assistive technology have been tetrachloroethylene has a range of established health and safety risks develop with high.... Studies are used to help us deliver content from their services the of. We also use cookies set by other sites to help us improve GOV.UK, remember your settings improve. It may also decrease the myocardial threshold to the arrhythmogenic action of injected.... Or disable the translated content using this setting perceptions have been tetrachloroethylene has been used medicinally in environment! Levels typically encountered in occupational or environmental exposures have not been well established their services cleaning operations, possibly... The liquid is irritating to the arrhythmogenic action of injected catecholamines ), for use in responding to a form. Develop with high exposures effects: chronic exposure may cause liver, it has not been well.... By other sites to help support any observed links ) exposure to tetrachloroethylene animals only cookies set other...: exposure can occur and is a colorless liquid with an ether-like odor ( on. Functioning, learning and memory, motor, attention, and possibly heart... Per million ( 1 ppm ) are limited side effects from the use! A mild, chloroform-like odor and is a colorless, heavy, non-inflammable and volatile liquid with mild. Ant1Helm1Nt1C agent also have been tetrachloroethylene has been used medicinally in the Truven health Analytics Inc. does not any.

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